Clinical studies and medical documentation

All clinical trials conducted at the hospital are listed and described on the GPR Hospital website under the “Clinical Trials” section. This allows patients to get an overview of the clinical trials offered at the GPR Hospital.

If interested, they can contact their treating physician or the “Research and Innovation” department directly. However, patients may also be approached by their physician about participating in a clinical trial.

Internal Medicine (Urinary Tract, Intestines, Lungs, Stomach, Other)

Overview of Studies

Clinical Picture	Study Name	Study Description	Information

Hyperparathyroidism—Parathyroid Disorder	StuDoQ	StuDoQ Registry Quality Assurance Study	Information Sheet
LARS Syndrome	CP DKZLARS	A multicenter, open-label, prospective, randomized, comparative study with two parallel follow-up regimens in patients with low anterior resection syndrome (LARS) following surgical treatment for rectal cancer	Information Sheet
Non-small-cell lung cancer	UmbREALung	A retrospective and prospective observational study involving multiple cohorts of patients with non-small cell lung cancer (NSCLC) receiving drugs approved for routine clinical use that were developed by AstraZeneca (AZ) or as part of an AZ alliance	Information Sheet
Renal Cell Carcinoma/Urothelial/ Bladder Carcinoma	CARAT	Clinical platform for research into molecular alterations and the treatment of renal cell carcinoma (mRCC)	Fact Sheet
Prostate Cancer	PROceed	A prospective, non-interventional study to investigate the clinical data and characteristics of patients with metastatic castration-resistant prostate cancer	Fact Sheet
Colon Cancer	COMPASS	A randomized, controlled, parallel-group, open-label, multicenter study to investigate mortality and quality of life following emergencies in obstructive colorectal cancer	Information Sheet
Orthopedics - Hip Surgery - Thrombosis Prevention	ENABLE-HIP	Multicenter randomized study on shortened anticoagulation therapy and increased mobilization following hip surgery	Information Sheet
Esophageal and Gastric Cancer	SAPHIR	Non-interventional study for patients with esophageal and gastric cancer	Information Sheet
Surgery - Hernias	Herniamed	Herniamed Quality Assurance Study	Information Sheet

Cardiology (Heart)

Overview of Studies

Clinical Picture	Study Name	Study Description	Information
Heart Rhythm Disorder/Atrial Fibrillation	CLEARANCE	Left Atrial Appendage Occlusion in Patients with Atrial Fibrillation and a History of Cerebral Hemorrhage Compared to Standard Medical Therapy: A Prospective Randomized Clinical Trial	Information Sheet
Atherosclerotic cardiovascular disease and elevated lipoprotein(a)	ACCLAIM-Lp(a)	This is a current Phase III study investigating the effect of the drug lepodisiran on the reduction of serious adverse cardiovascular events in adults with elevated lipoprotein(a)	Information Sheet

Breast Cancer Center and Gynecologic Cancer Center

Overview of Studies

Clinical Picture	Study Name	Study Description	Information
Breast Cancer	CAROLEEN	A non-interventional study of Kisqali (ribociclib) in combination with an aromatase inhibitor for the adjuvant treatment of patients with HR+/HER2- early-stage breast cancer at high risk of recurrence to evaluate efficacy, the safety profile, adherence, and quality of life	Information Sheet
Breast Cancer	OPAL	Study for women with breast cancer. Treatment data and questionnaire responses will be collected from the participants. This is an observational study and will not influence the treatment method prescribed by the physician.	Information Sheet
Breast Cancer	PERFORM	An epidemiological, prospective observational study investigating the actual care received by patients with HR+/HER2- advanced breast cancer who are treated in the first-line setting with an endocrine-based palbociclib combination therapy in accordance with current treatment standards	Information Sheet
Breast Cancer	LOBSTER	A Phase II neoadjuvant study to evaluate capivasertib plus fulvestrant compared to fulvestrant alone in patients with primary lobular breast cancer and a high risk of recurrence	Fact Sheet
Breast Cancer	CAPTOR-BC	Study for Women with Breast Cancer to Document the Combination of Rivociclib and Endocrine Therapy	Information Sheet
Breast Cancer	CAMBRIA 1	An open-label, randomized Phase III study to evaluate the efficacy and safety of extended therapy with camizestrant	Information Sheet
Breast Cancer	FLAMINGO 1	A clinical, randomized, multicenter Phase III adjuvant immunotherapy trial with GLSI-100 to prevent the recurrence of breast cancer in HER2+ and HLA-A*02 patients	Information Sheet
Ovarian/Endometrial Cancer	SMARAGD	National, prospective, open-label, longitudinal, non-interventional, multicenter observational study (tumor registry).	Information Sheet