Information sheet on the clinical study - WEGIO study

Main indication

Significant overweight in children

Study name (study type)

WEGIO Study (Whole Genetic Approach in Early Genetic Identification of Obesity)

Study sponsor

Rolfs Consulting and Management GmbH 

Prof. Dr. Arndt Rolfs

Leibnitzerstr. 58

10629 Berlin

FOR READERS IN A HURRY:

Severe obesity is a multifactorial disease attributable to genetic, environmental, behavioral, and metabolic factors. The aim of the study is to understand the role of genetics in severe obesity. 

DETAILED INFORMATION:

Severe obesity means that a lot of fat has accumulated in the body. Sometimes this happens due to factors like genetic information. 

It’s important to know why someone is severely overweight so that doctors can find the best way to help. 

Sometimes it’s because the genetic makeup in the body is different from that of other people. With a special study, we can better understand why this happens. Then doctors can also better figure out how to help.

Study Title

Genetic Analysis for the Early Diagnosis of Severe Obesity.

What is being analyzed in this study?

A positivity rate of 4% is predicted, meaning that approximately 40 out of 1,000 people have a definitive genetic cause for severe obesity. 

Study Procedure

During the first visit, a physical examination, blood sample collection, and documentation of general clinical data will take place.

If a genetic condition is diagnosed, a second visit will be scheduled to discuss the nature of the condition and potential treatment options. 

Inclusion Criteria

• Participants must be 2 years of age or older with parental consent, currently have or have had a body weight > 97th percentile before the age of 6, and exhibit one or more of the following symptoms: rod-cone dystrophy, renal anomaly, ataxia, syndactyly, polydactyly, brachydactyly, hyperphagia, cognitive impairment, speech delay, or hypogonadism
• The participant is 18 years of age or older with a BMI > 30 kg/m² and, prior to age 6, a body weight > 97th percentile and rod-cone dystrophy
• The participant is at least 2 years old, has a clinical diagnosis of Bardet-Biedl syndrome, or is a sibling of a person diagnosed with BBS as part of the WEGIO study. 

Exclusion criteria

• Failure to meet the inclusion criteria

   

Your contacts: Investigators at the center and contact information

Dr. Christiane Wiethoff, MD – Chief Physician of the Department of Pediatrics and Adolescent Medicine

Responsible staff members in the study clinic

Heike Borchert (Study Coordinator)

Email: borchert@~@gp-ruesselsheim.de

Phone: 06142 88-1032